-
Archivos de Bronconeumologia Feb 2023
Topics: Humans; Leiomyoma; Lung Neoplasms; Bronchial Neoplasms
PubMed: 36153217
DOI: 10.1016/j.arbres.2022.08.007 -
Thorax Jul 1972A series comprising 26 patients with bronchial adenoma, consisting of 23 carcinoid tumours, 2 mucoepidermoid tumours, and 1 cylindroma, treated during the period 1956-71...
A series comprising 26 patients with bronchial adenoma, consisting of 23 carcinoid tumours, 2 mucoepidermoid tumours, and 1 cylindroma, treated during the period 1956-71 is presented. Eighteen of the carcinoid adenomas showed invasive growth, and six had metastases, five with lymph node metastases and one with hepatic metastases without node involvement (Case 17) at the time of operation. Both of the mucoepidermoid tumours and the cylindroma showed invasive growth, and one of the former had metastases. The average history of the patients was three to six months. The diagnosis was established preoperatively in 13 cases. It should be stressed that a cytological examination in 21 patients revealed pathological cells in seven. The patients have been treated according to the same principles followed in the case of malignant lung tumours. Four patients died owing to progression of the tumour, two from complicating diseases, and four from postoperative complications. Sixteen patients are alive and have been followed up. Three of these patients have been submitted to a non-curative operation. One year later they show no clinical signs of tumour progression. Twelve patients were submitted to a curative operation six months to 15 years before the follow-up. None shows any signs of recurrence. One patient refused operation. The five-year survival rate for lung carcinoids was 56%, or 68% after exclusion of four immediate postoperative deaths. It is concluded that bronchial adenomas are potentially malignant tumours and should be treated like other malignant lung tumours; because of their slow growth rate and the later development of metastases, extensive operations in cases of invasive tumours and reoperations in cases of recurrence may be carried out with good results. It is further concluded that cytological examinations have greater value than was hitherto assumed.
Topics: Adenoma; Adolescent; Adult; Aged; Bronchial Neoplasms; Carcinoid Tumor; Carcinoma; Carcinoma, Adenoid Cystic; Female; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Postoperative Complications
PubMed: 4342435
DOI: 10.1136/thx.27.4.442 -
Journal of Thoracic Oncology : Official... Apr 2009Preinvasive lesions are considered the precursors of squamous cell carcinoma of the bronchus. Treatment at the preinvasive stage, before the potential for metastasis,... (Review)
Review
Preinvasive lesions are considered the precursors of squamous cell carcinoma of the bronchus. Treatment at the preinvasive stage, before the potential for metastasis, may improve survival from squamous cell carcinoma. An understanding of the natural history and outcome of preinvasive lesions is essential for the accurate interpretation studies of their treatment, and decisions regarding the management of individual lesions. The natural history of preinvasive lesions has only been reported in a small number of highly selected patients and uses different inclusion criteria, treatment criteria. and time-periods of follow-up, making it difficult to draw definitive conclusions. High-grade preinvasive lesions carry a risk of progression to carcinoma but most patients have multiple lesions and a significant probability of developing new lesions over time. Distinguishing lesions with malignant potential, the targets for therapy, from those that will regress or remain indolent is difficult. The American College of Chest Physicians guidelines recommend bronchoscopic follow-up of severe dysplasia and carcinoma-in situ. This review of the evidence regarding the natural history and outcome of preinvasive lesions supports this view, but also shows that further studies in individuals at risk for lung cancer are necessary before guidelines for the management of preinvasive lesions can be developed.
Topics: Bronchial Neoplasms; Carcinoma, Squamous Cell; Humans; Precancerous Conditions; Prevalence
PubMed: 19279508
DOI: 10.1097/JTO.0b013e31819667bd -
Thorax Feb 1982
Topics: Bronchial Neoplasms; Calcinosis; Child, Preschool; Female; Humans; Lung; Radiography; Teratoma; Thymus Gland
PubMed: 7080019
DOI: 10.1136/thx.37.2.157 -
Thorax Jul 1973The indications and techniques for performing the operation of anterior mediastinotomy are described. In the years 1966-71, 116 anterior mediastinotomies were done. The...
The indications and techniques for performing the operation of anterior mediastinotomy are described. In the years 1966-71, 116 anterior mediastinotomies were done. The results of these are presented. In 36 patients the operation was done to provide a histological diagnosis in benign conditions. In 51 patients, with probable carcinoma but normal bronchoscopy, mediastinotomy was done to establish a diagnosis and assess operability; 43 had involved mediastinal nodes proven on histology. In a further 29 patients, with positive bronchoscopic biopsies, mediastinotomy was done to assess operability alone. In all, 14 patients (17·5%) were judged suitable for thoracotomy. Of these, nine had operable disease while five were found to be inoperable. The incidence of complications of the operation was low (11%). These were mostly minor, There were no deaths. Most patients, after anterior mediastinotomy alone, were fit for discharge 48 to 72 hours after the operation. The value of an operation that provides both diagnosis and assessment of mediastinum, lung, and pleura is discussed. The operation of anterior mediastinotomy is compared with mediastinoscopy and, in our opinion, the superiority of the former is demonstrated.
Topics: Biopsy; Bronchial Neoplasms; Bronchoscopy; Humans; Lung Diseases; Lung Neoplasms; Mediastinal Neoplasms; Mediastinum; Methods; Postoperative Complications; Sarcoidosis; Surgical Wound Infection
PubMed: 4741446
DOI: 10.1136/thx.28.4.444 -
The Korean Journal of Internal Medicine Jun 2011We made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy. (Review)
Review
BACKGROUND/AIMS
We made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy.
METHODS
Qualified studies regarding endoscopic cryotherapy of lung tumors were systemically evaluated using available databases according to predefined criteria.
RESULTS
In total, 16 publications were included in the final assessment. A narrative synthesis was performed because a formal meta-analysis was not viable due to the lack of controlled studies and study heterogeneity. Overall success rates for significant recanalization of the obstruction were approximately 80%, although they varied, depending on disease status in the patient population. Complications from the procedure developed in 0-11.1% of cases, most of which were minor and controlled by conservative management. Although limited data were available on comprehensive functional assessment, some studies showed that respiratory symptoms, pulmonary function tests, and performance status were significantly improved.
CONCLUSIONS
Endoscopic cryotherapy was found to be a safe and useful procedure in the management of endobronchial tumors although its efficacy and appropriate indications have yet to be determined in well-designed controlled studies.
Topics: Bronchial Neoplasms; Bronchoscopy; Cryosurgery; Humans; Lung Neoplasms; Neoplasm Staging; Risk Assessment; Treatment Outcome
PubMed: 21716589
DOI: 10.3904/kjim.2011.26.2.137 -
Bulletin Du Cancer Jun 2011Carcinoid tumors are the most common endobronchial tumors in the pediatric population, and represent a rare cause of airway obstruction. Clinical manifestations are... (Review)
Review
Carcinoid tumors are the most common endobronchial tumors in the pediatric population, and represent a rare cause of airway obstruction. Clinical manifestations are unspecific, and diagnosis is often delayed due to low clinical suspicion. These tumors are considered low-grade malignant neoplasms, and their evolution is usually favorable after surgery. However, local recurrence and/or metastases can occur with both typical and atypical carcinoid tumors, justifying the need of prompt diagnosis and long-term follow-up.
Topics: Bronchial Neoplasms; Carcinoid Tumor; Child; Humans; Neoplasm Recurrence, Local; Prognosis
PubMed: 21622089
DOI: 10.1684/bdc.2011.1369 -
Revista Portuguesa de Pneumologia 2012Pulmonary myxoma is an extremely rare benign neoplasm. It is mostly parenchymal but may occasionally occur within the tracheobronchial tree. There are very few reports...
INTRODUCTION
Pulmonary myxoma is an extremely rare benign neoplasm. It is mostly parenchymal but may occasionally occur within the tracheobronchial tree. There are very few reports of endobronchial myxoma.
CASE REPORT
We describe a case of endobronchial myxoma in a 40-year-old female patient with a history of asthma and repeated right-sided pneumonia. Thoracic computed tomography (CT) showed medium lobe atelectasis. Fiber optic bronchoscopy revealed a polypoid, well-circumscribed tumor, causing total obstruction of the medium lobe bronchus. Biopsy of the mass was non-diagnostic. Further study included a positron emission tomography (PET) which demonstrated low metabolic activity of the tumor and no evidence of neoplasia in other location. The patient was submitted to a medium lobectomy and microscopic examination of the tumor revealed myxoid stroma with lobulated pattern, elongated and stellate cells, compatible with myxoma.
CONCLUSION
Pulmonary myxoma is extraordinary rare and endobronchial location is very few reported in medical literature.
Topics: Adult; Bronchial Neoplasms; Female; Humans; Myxoma
PubMed: 22261261
DOI: 10.1016/j.rppneu.2011.12.004 -
Sao Paulo Medical Journal = Revista... Nov 2000Oncocytomas are generally small and present slow growth. Finding of the tumor usually occurs incidentally. Their incidence is higher among male patients. Oncocytomas in...
CONTEXT
Oncocytomas are generally small and present slow growth. Finding of the tumor usually occurs incidentally. Their incidence is higher among male patients. Oncocytomas in mucous bronchial glands are extremely rare.
CASE REPORT
A 35-year-old male who presented bronchial oncocytoma. The tumor was found after bronchoscopy that investigated an atelectasis of the upper left lobe. Histological examination with optical microscopy revealed a mature neoplasm formed by ovoid cells with thin, granular, eosinophilic cytoplasm and small nuclei similar to oncocytes. Electron microscopy showed mitochondrial hyperplasia. A three-year follow-up after thoracotomy followed by lobectomy and removal of the bronchial tumor was uneventful.
Topics: Adenoma, Oxyphilic; Adult; Bronchial Neoplasms; Follow-Up Studies; Humans; Male
PubMed: 11120552
DOI: 10.1590/s1516-31802000000600009 -
BMC Pulmonary Medicine Sep 2020Endobronchial lipoma is an extremely rare benign tumor, which is generally located in the first three subdivisions of the tracheobronchial tree. According to the...
BACKGROUND
Endobronchial lipoma is an extremely rare benign tumor, which is generally located in the first three subdivisions of the tracheobronchial tree. According to the existing literature, all endobronchial lipomas are single (one per patient). Here, we report a rare case in which the patient presented with two endobronchial lipomas in the same patient, and underwent a bronchoscopic tumor resection in the left main bronchus and the left lower bronchus. Both tumors were pathologically confirmed as endobronchial lipoma.
CASE PRESENTATION
A 52-year-old Chinese man presented at the clinic reporting a mild cough with yellow color sputum and exertional dyspnea for 2 weeks. He was a heavy smoker (45 pack-years). Chest auscultation demonstrated faint wheezing in left lower lobe. Computed tomography (CT) revealed two low-density endobronchial masses located in the middle segment of the left main bronchus and the posterior basilar segmental bronchus of the left lower lobe. The neoplasms measured a CT-attenuation value of -70HU, -98HU in density with air trapping and atelectasis in the segmental bronchus of the left lower lobe. The patient underwent interventional bronchoscopic management to remove the neoplasms by using an electrosurgical snare, cryotherapy, and electrocautery. The locations of the neoplasms were confirmed at the left main bronchus and the superior segment of the left lower lobe during bronchoscopic intervention. Histopathological examination confirmed that both tissues were consistent with lipomas. After 18 months of follow-up, the patient was free of symptoms and CT revealed that bronchiectasia remained in the superior segment of the left lower lobe; however, no mass lesion was present in the left bronchus.
CONCLUSIONS
This case suggests that an endobronchial lipoma can present as multiple lesions, and both proximal and distal types can simultaneously occur in the same patient. Thus, these findings help us further understand the biology of endobronchial lipomas.
Topics: Bronchial Neoplasms; Bronchoscopy; Dyspnea; Humans; Lipoma; Male; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 32962678
DOI: 10.1186/s12890-020-01287-4